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Gaining public attention among men worldwide because of its efficacy in treating erectile dysfunction is Vardenafil HCI. Men who have used Levitra vouched for its usefulness and were happy enough as it improved their sexual life.
Dosage and Administration: - Available in the following dosage: 2.5 mg, 5 mg, 10 mg and 20 mg tablets. - Starting dose: 10 mg taken as needed approximately 25 – 20 minutes before sexual activity - Range of dose: It can be increased to 20 mg or decreased to 5 mg depending on efficacy and tolerability. - Maximum recommended dose: 20 mg once a day. A maximum dose of 5 mg should not be exceeded when used in combination with the potent cytochrome P-450 (CYP)3A4 inhibitors ketoconazole, itraconazole, indinavir and ritonavir. A maximum dose of 10 mg should not be exceeded when used in combination with the CYP3A4 inhibitor erythromycin. - For elderly (>65 years): No dose adjustment is required. - For patients with hepatic impairment: No dose adjustment is needed in patients with mild hepatic impairment. It is, however, reduced in patients with moderate hepatic impairment supporting a starting dose of 5 mg and may be subsequently increased to 10 mg and then 20 mg depending on tolerability and efficacy. The pharmacokinetics of Levitra has not been studied in patients with severe hepatic impairment.
Overdosage Vardenafil HCI was tested in single dose volunteer studies in doses up to and including 80 mg/day. It was shown that even the highest dosage of 80 mg/day was tolerated without producing serious adverse effects. This was confirmed in a study with 40 mg once-daily doses >4 weeks. Cases of severe back pain were observed when 40 mg was administered twice daily, No muscle or neurological toxicity was reported. Supportive measures should be taken as required in cases of overdose.